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Melos is the first oral gel with melatonin (2%) and chlorhexidine (0.12%) useful to counteract oxidative stress at the level of the mouth and outbuildings. Oxidative stress is manifested in the form of alterations of the mucous membranes that cover the mouth. It was designed to act quickly in mucositis, better known as stomatitis. It's also active in oral cancers, in periodontitis, the canker sores, gingivitis and is in a valid adjuvant during the common toothache and trigeminal neuralgia. The gel formulation allows for more focused and activity of the active site. Melos is enriched with natural substances such as Calendula, Melaleuca, Lavender etc. Melos is a patent pending oral gel and, in our patent, we claim the sinergy of actions of Melatonin with Chlorhexidine.
Melathonin acts as a powerful antioxidant. Acts directly against the free radicals of oxygen and nitrogen. Acts indirectly by promoting the endogenous production of catalase, superoxide dismutase and glutathione.
Prevents, therefore, the inflammation that is generated for the uncontrolled activity of free radicals.
Melathonin also owns immonostimolant properties. Increase the 'interleukin type 2 CD4 + lymphocytes and interferon gamma.
It also reduces fungal infections by promoting the phagocytic activity of defensive cells of our body.
Attenuates viral infections for the increased production of IL-1 beta.
Melathonin is a natural anti-inflammatory and inhibits the COX-2 enzyme by binding to the active sites of COX-1 and COX-2.
Has a direct anticancer effect, inhibiting the growth of cancer cells.
For these reasons, may find application in oral cancers and effectively counteractes the effects of chemotherapy and radiotherapy which are manifested as mucositis and other oral disease.
Chlorhexidine is an antiseptic and is active against Gram +, Gram - and fungi.
It creates a synergy of actions between melatonin and chlorhexidine. Chlorhexidine eliminates the surplus of bacterial and fungal infection and promotes an intense and profound understanding of melatonin.
Melos may be used in children in the wounds of prostheses and teething pains. Also it is a valid adjuvant in chemotherapy. In this case it can be used between one cycle and the next; or as prevention of mucositis before starting a cycle.
Melos is active after the first 3 days of treatment and the effects are spread over even after treatment has stopped.
mucositis, periodontal disease, candidiasis, aphta, gingivitis, toothache
|How to use||Apply 2-3 times a day on the area to be treated|
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